Use of columns with amine and nitrile sorbents for hydrophylic interaction liquid chromatography

Ведомости Научного центра экспертизы средств медицинского применения

A. S. Osipov¹  O. A. Popova¹  T. N. Gretskaya¹  M. V. Nezdolieva¹  A. I. Sulimenkova¹ 

[1] Scientific Centre for Expert Evaluation of Medicinal Products;

关键词: высокоэффективная жидкостная хроматография;    жидкостная хроматография гидрофильных взаимодействий;    хроматографические колонки;    нитрильные сорбенты;    аминосорбенты;    high performance liquid chromatography;    hydrophilic interaction liquid chromatography;    chromatographic columns;    nitrile sorbents;    amine sorbents;   

DOI  :  

来源: DOAJ

【 摘 要 】

The article summarizes the conclusions contained in the authors’ papers on hydrophilic interaction liquid chromatography published in 2010-2016. Chromatographic columns with amine sorbents can perform differently from chromatographic columns with nitrile sorbents in hydrophilic interaction liquid chromatography depending on the products analysed. Chromatographic columns with amine sorbents can be used in the analysis of both hydrophilic compounds and some hydrophobic compounds (nitro compounds, butylhydroxyanisole, parabens). Chromatographic columns with nitrile sorbents can only be used for the analysis of hydrophilic compounds (urea, hydroxyurea) and platinum coordination compounds.

【 授权许可】

Unknown