Emerging roles and regulation of MiT/TFE transcriptional factors

Cell Communication and Signaling

Xuemei Sun¹  Min Yang¹  Bo Tang¹  Shi-Ming Yang¹  Li Tang¹  Hui Dong¹  En Liu¹  Yuanyuan Lei¹  Jiaxi Hu¹  Mingfa Gao² 

[1] Department of Gastroenterology, Xinqiao Hospital, Third Military Medical University (Army Medical University);Department of Hepatobiliary Surgery, Xinqiao Hospital, Third Military Medical University (Army Medical University);

关键词: TFEB;    TFE3;    MiT/TFE family;    Lysosome;    Autophagy;    Cancer;   

DOI  :  10.1186/s12964-018-0242-1

来源: DOAJ

【 摘 要 】

Abstract The MiT/TFE transcription factors play a pivotal role in the regulation of autophagy and lysosomal biogenesis. The subcellular localization and activity of MiT/TFE proteins are primarily regulated through phosphorylation. And the phosphorylated protein is retained in the cytoplasm and subsequently translocates to the nucleus upon dephosphorylation, where it stimulates the expression of hundreds of genes, leading to lysosomal biogenesis and autophagy induction. The transcription factor-mediated lysosome-to-nucleus signaling can be directly controlled by several signaling molecules involved in the mTORC1, PKC, and AKT pathways. MiT/TFE family members have attracted much attention owing to their intracellular clearance of pathogenic factors in numerous diseases. Recently, multiple studies have also revealed the MiT/TFE proteins as master regulators of cellular metabolic reprogramming, converging on autophagic and lysosomal function and playing a critical role in cancer, suggesting that novel therapeutic strategies could be based on the modulation of MiT/TFE family member activity. Here, we present an overview of the latest research on MiT/TFE transcriptional factors and their potential mechanisms in cancer.

【 授权许可】

Unknown