Piper Species: A Comprehensive Review on Their Phytochemistry, Biological Activities and Applications

Molecules

ZainulAmiruddin Zakaria¹  Javad Sharifi-Rad²  Adem Ozleyen²  Jovana Rajkovic³  Rabin Gyawali³  Miquel Martorell⁴  Lianet Monzote Fidalgo⁵  Elif Turkdonmez⁶  TugbaBoyunegmez Tumer⁷  Marco Valussi⁷  Tariq Khan⁸  WilliamN. Setzer⁹  Bahare Salehi^1,10  SalamA. Ibrahim^1,11  ZabtaKhan Shinwari^1,11 

[1] Department of Biomedical Science, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia;Department of Biotechnology, Quaid-i-Azam University, Islamabad 45320, Pakistan;;Department of Food and Nutritional Sciences, North Carolina A&Department of Molecular Biology and Genetics, Faculty of Arts and Science, Canakkale Onsekiz Mart University, 17020 Canakkale, Turkey;European Herbal and Traditional Medicine Practitioners Association (EHTPA), 25 Lincoln Close, Tewkesbury GL20 5TY, UK;Food Safety Research Center (salt), Semnan University of Medical Sciences, Semnan 35198-99951, Iran;Graduate Program of Biomolecular Sciences, Institute of Natural and Applied Sciences, Canakkale Onsekiz Mart University, 17020 Canakkale, Turkey;Institute of Pharmacology, Clinical Pharmacology and Toxicology, Medical Faculty, University of Belgrade, 11129 Belgrade, Serbia;Parasitology Department, Institute of Tropical Medicine “Pedro Kouri”, Havana 10400, Cuba;Student Research Committee, School of Medicine, Bam University of Medical Sciences, Bam 44340847, Iran;T State University, Greensboro, NC 27411, USA;

关键词: pepper;    essential oil;    antimicrobial;    traditional medicine;    anticancer;    anti-inflammatory;   

DOI  :  10.3390/molecules24071364

来源: DOAJ

【 摘 要 】

Piper species are aromatic plants used as spices in the kitchen, but their secondary metabolites have also shown biological effects on human health. These plants are rich in essential oils, which can be found in their fruits, seeds, leaves, branches, roots and stems. Some Piper species have simple chemical profiles, while others, such as Piper nigrum, Piper betle, and Piper auritum, contain very diverse suites of secondary metabolites. In traditional medicine, Piper species have been used worldwide to treat several diseases such as urological problems, skin, liver and stomach ailments, for wound healing, and as antipyretic and anti-inflammatory agents. In addition, Piper species could be used as natural antioxidants and antimicrobial agents in food preservation. The phytochemicals and essential oils of Piper species have shown strong antioxidant activity, in comparison with synthetic antioxidants, and demonstrated antibacterial and antifungal activities against human pathogens. Moreover, Piper species possess therapeutic and preventive potential against several chronic disorders. Among the functional properties of Piper plants/extracts/active components the antiproliferative, anti-inflammatory, and neuropharmacological activities of the extracts and extract-derived bioactive constituents are thought to be key effects for the protection against chronic conditions, based on preclinical in vitro and in vivo studies, besides clinical studies. Habitats and cultivation of Piper species are also covered in this review. In this current work, available literature of chemical constituents of the essential oils Piper plants, their use in traditional medicine, their applications as a food preservative, their antiparasitic activities and other important biological activities are reviewed.

【 授权许可】

Unknown