Environmental risk characteristics of bacterial antibiotic resistome in Antarctic krill

Ecotoxicology and Environmental Safety

Jianguo He¹  Zhili He²  Shaoping Weng³  Lingbo Ma⁴  Lumin Wang⁴  Yuanyuan Wang⁵  Jian He⁵  Zhimin Li⁵  Muhua Wang⁵  Changjun Guo⁵  Zixuan Liu⁵ 

[1]Guangdong Provincial Key Laboratory of Marine Resources, and Coastal Engineering and Guangdong Province Key Laboratory for Aquatic Economic Animals, Sun Yat-sen University, 135 Xingang Road West, Guangzhou 510275, PR China

[2]Environmental Microbiomics Research Center, School of Environmental Science and Engineering, Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai), Sun Yat-sen University, Guangzhou 510006, China

[3]Guangdong Provincial Key Laboratory of Marine Resources, and Coastal Engineering and Guangdong Province Key Laboratory for Aquatic Economic Animals, Sun Yat-sen University, 135 Xingang Road West, Guangzhou 510275, PR China

[4]Key Laboratory of the East China Sea and Oceanic Fishery Resources Exploitation, Ministry of Agriculture, East China Sea Fisheries Research Institute, Shanghai 116023, PR China

[5]State Key Laboratory for Biocontrol, Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai), School of Marine, Sun Yat-sen University, 135 Xingang Road West, Guangzhou 510275, PR China

关键词: Antarctica;    Antibiotic resistance genes;    Antarctic krill;    Ecological risks;   

DOI  :  

来源: DOAJ

【 摘 要 】

Antibiotic resistance genes (ARGs) are ubiquitous in nature, especially in the current era of antibiotic abuse, and their existence is a global concern. In the present study, we discovered that Antarctic krill-related culturable bacteria are resistant to β-lactam, tetracyclines, aminoglycosides, and sulphamethoxazole/trimethoprim based on the antibiotic efflux mechanism. In addition, the co-occurrence of ARGs with insertion sequence (IS) (tnpA, IS91) and Intl1 on the isolates and the phylogenetic analysis results of the whole-genome revealed low-frequency ARG transfer events, implying the transferability of these ARGs. These findings provide an early warning for the wide assessment of Antarctic microbiota in the spread of ARGs. Our work provides novel insights into understanding ARGs in culturable host-associated microorganisms, and their ecological risks and has important implications for future risk assessments of antibiotic resistance in extreme environments.

【 授权许可】

Unknown