Physical Exercise Restrains Cancer Progression through Muscle-Derived Factors

Cancers

Meletios-Athanasios Dimopoulos¹  Flora Zagouri¹  Michael Koutsilieris²  Anastassios Philippou²  Argyro Papadopetraki²  Maria Maridaki³ 

[1] Department of Clinical Therapeutics, Alexandra Hospital, Medical School, National and Kapodistrian University of Athens, 11528 Athens, Greece;Department of Physiology, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece;Faculty of Physical Education and Sport Science, National and Kapodistrian University of Athens, 17237 Dafne, Greece;

关键词: physical activity;    exercise;    muscle-derived factors;    cancer;    myokines;    miRNAs;   

DOI  :  10.3390/cancers14081892

来源: DOAJ

【 摘 要 】

A growing body of in vitro and in vivo studies suggests that physical activity offers important benefits against cancer, in terms of both prevention and treatment. However, the exact mechanisms implicated in the anticancer effects of exercise remain to be further elucidated. Muscle-secreted factors in response to contraction have been proposed to mediate the physical exercise-induced beneficial effects and be responsible for the inter-tissue communications. Specifically, myokines and microRNAs (miRNAs) constitute the most studied components of the skeletal muscle secretome that appear to affect the malignancy, either directly by possessing antioncogenic properties, or indirectly by mobilizing the antitumor immune responses. Moreover, some of these factors are capable of mitigating serious, disease-associated adverse effects that deteriorate patients’ quality of life and prognosis. The present review summarizes the myokines and miRNAs that may have potent anticancer properties and the expression of which is induced by physical exercise, while the mechanisms of secretion and intercellular transportation of these factors are also discussed.

【 授权许可】

Unknown