Radiobiological and Treatment-Related Aspects of Spatially Fractionated Radiotherapy

International Journal of Molecular Sciences

Loredana G. Marcu¹  Leyla Moghaddasi²  Paul Reid³  Eva Bezak⁴ 

[1] Cancer Research Institute, University of South Australia, Adelaide, SA 5001, Australia;Department of Medical Physics, Austin Health, Ballarat, VIC 3350, Australia;Radiation Health, Environment Protection Authority, Adelaide, SA 5000, Australia;School of Physical Sciences, University of Adelaide, Adelaide, SA 5001, Australia;

关键词: non-conventional radiotherapy;    GRID radiotherapy;    protons;    organ sparing;    therapeutic index;   

DOI  :  10.3390/ijms23063366

来源: DOAJ

【 摘 要 】

The continuously evolving field of radiotherapy aims to devise and implement techniques that allow for greater tumour control and better sparing of critical organs. Investigations into the complexity of tumour radiobiology confirmed the high heterogeneity of tumours as being responsible for the often poor treatment outcome. Hypoxic subvolumes, a subpopulation of cancer stem cells, as well as the inherent or acquired radioresistance define tumour aggressiveness and metastatic potential, which remain a therapeutic challenge. Non-conventional irradiation techniques, such as spatially fractionated radiotherapy, have been developed to tackle some of these challenges and to offer a high therapeutic index when treating radioresistant tumours. The goal of this article was to highlight the current knowledge on the molecular and radiobiological mechanisms behind spatially fractionated radiotherapy and to present the up-to-date preclinical and clinical evidence towards the therapeutic potential of this technique involving both photon and proton beams.

【 授权许可】

Unknown