Control of adaptive action selection by secondary motor cortex during flexible visual categorization

eLife

Jing Liu¹  Haishan Yao²  Tian-Yi Wang² 

[1] University of Chinese Academy of Sciences, Beijing, China;Institute of Neuroscience, State Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, China;

关键词: flexible behavior;    computational model;    chemogenetic manipulation;    secondary motor cortex;    in vivo recording;   

DOI  :  10.7554/eLife.54474

来源: DOAJ

【 摘 要 】

Adaptive action selection during stimulus categorization is an important feature of flexible behavior. To examine neural mechanism underlying this process, we trained mice to categorize the spatial frequencies of visual stimuli according to a boundary that changed between blocks of trials in a session. Using a model with a dynamic decision criterion, we found that sensory history was important for adaptive action selection after the switch of boundary. Bilateral inactivation of the secondary motor cortex (M2) impaired adaptive action selection by reducing the behavioral influence of sensory history. Electrophysiological recordings showed that M2 neurons carried more information about upcoming choice and previous sensory stimuli when sensorimotor association was being remapped than when it was stable. Thus, M2 causally contributes to flexible action selection during stimulus categorization, with the representations of upcoming choice and sensory history regulated by the demand to remap stimulus-action association.

【 授权许可】

Unknown