Apoptosis in premalignant and malignant squamous cell lesions of the oral cavity: A light microscopic study

Indian Journal of Pathology and Microbiology

关键词: Apoptotic index;    dysplasia;    oral cavity;    squamous cell carcinoma;   

DOI  :  

来源: DOAJ

【 摘 要 】

Background:Oral cancers are a major health problem in India. Recently, parameters of cell proliferation and cell death have emerged as important diagnostic and prognostic tools. Aims:The aim was to study apoptosis in premalignant and malignant squamous cell lesions of the oral cavity and to evaluate its prognostic role in oral cancers. Materials and Methods:The study included 175 patients presenting with oral lesions. Evaluation of apoptotic index (AI) (using light microscopy) was performed on hematoxylin and eosin-stained sections. Statistical Analysis Used:Student′s t test was performed. Results:The mean AI increased progressively with increasing dysplasia, with the maximum AI in well-differentiated (WD) squamous cell carcinoma, and a fall was noted with progression toward higher grades. The difference between WD SCC and poorly-differentiated SCC was significant (P < 0.05). Cases with lymph node metastasis had significantly (P < 0.05) lower mean AI values. Conclusion:Apoptosis can be fairly accurately assessed using light microscopy. Tumors that exhibit less apoptosis tend to show aggressive behavior and have a greater potential for metastasis.

【 授权许可】

Unknown