The Importance of Vascular Endothelial Growth Factor (VEGF) in Aggressiveness of Odontogenic Lesions

Journal of Clinical and Diagnostic Research

Reham Alsafadi¹  Mamdouh Almohareb¹ 

[1] Department of Oral Histology and Pathology, Faculty of Dentistry-Damascus University, Damascus, Syria.;

关键词: ameloblastoma;    dentigerous cyst;    diagnostic techniques;   

DOI  :  10.7860/JCDR/2019/40465.12810

来源: DOAJ

【 摘 要 】

Introduction: Angiogenesis is a major part of a variety of physiological and pathological processes, including tumour growth. Vascular Endothelial Growth Factor (VEGF) is a highly potent and specific angiogenic factor. Many studies have indicated the importance of VEGF in growth and expansion of lesions which contributes to the local invasion of odontogenic lesions. Aim: To investigate the expression of VEGF in Ameloblastoma and Dentigerous Cyst, using a monoclonal antibody, then compare between them to investigate the role in diagnosis and determination of biological behaviour of some odontogenic lesions. Materials and Methods: The sample consisted of 15 formalinfixed, paraffin-embedded specimens of Ameloblastoma (Follicular-plexiform pattern) and 15 cases of Dentigerous Cyst that were conventionally stained with H and E and immunohistochemically stained with a monoclonal anti-VEGF antibody. VEGF expression in this specimen was qualitatively evaluated, calculating the percentage of VEGF positive cells in the epithelial and stromal cells. Results: The expression of VEGF in Ameloblastoma (Follicularplexiform subtype) was varied between high and medial while its expression in Dentigerous Cyst was low, the statistical analysis indicated significant differences between these lesions (p<0.05). Conclusion: VEGF contributes to the invasion of aggressive odontogenic lesions, thus we concluded its role as diagnostic and prognostic markers in the prediction of the biological behaviour of odontogenic lesions.

【 授权许可】

Unknown