The Impact of Lifestyle Interventions in High-Risk Early Breast Cancer Patients: A Modeling Approach from a Single Institution Experience

Cancers

Elena Barbieri¹  Valentina Natalucci¹  Maria Gabriella Ceravolo²  Marianna Capecci²  Giulia Nicolai³  Sonia Crocetti⁴  Agnese Savini⁴  Filippo Merloni⁴  Edoardo Lenci⁴  Lucia Bastianelli⁴  Rossana Berardi⁴  Zelmira Ballatore⁴  Veronica Agostinelli⁴  Mirco Pistelli⁴  Laura Scortichini⁴  Claudia Cola⁵  Daniele Fumelli⁵  Albano Nicolai⁵  Marina Taus⁵  Gloria Giulietti⁵  Maurizio Ricci⁶  Roberta Serrani⁶ 

[1] Department of Biomolecular Sciences, University of Urbino Carlo Bo, 61029 Urbino, Italy;Department of Experimental and Clinical Medicine, Neurorehabilitation Clinic, Università Politecnica delle Marche, AOU Ospedali Riuniti di Ancona, 60126 Ancona, Italy;Department of Medical Emergency, AOU Ospedali Riuniti Marche Nord, 61121 Pesaro, Italy;Department of Medical Oncology, Università Politecnica delle Marche, AOU Ospedali Riuniti di Ancona, 60126 Ancona, Italy;Dietology and Clinical Nutrition, AOU Ospedali Riuniti di Ancona, 60126 Ancona, Italy;Division of Rehabilitation Medicine, AOU Ospedali Riuniti di Ancona, 60126 Ancona, Italy;

关键词: lifestyle;    physical activity;    Mediterranean diet;    obesity;    metabolic syndrome;    anxiety;   

DOI  :  10.3390/cancers13215539

来源: DOAJ

【 摘 要 】

A healthy lifestyle plays a strategic role in the prevention of BC. The aim of our prospective study is to evaluate the effects of a lifestyle interventions program based on special exercise and nutrition education on weight, psycho-physical well-being, blood lipid and hormonal profile among BC patients who underwent primary surgery. From January 2014 to March 2017, a multidisciplinary group of oncologists, dieticians, physiatrists and an exercise specialist evaluated 98 adult BC female patients at baseline and at different time points. The patients had at least one of the following risk factors: BMI ≥ 25 kg/m², high testosterone levels, high serum insulin levels or diagnosis of MS. Statistically significant differences are shown in terms of BMI variation with the lifestyle interventions program, as well as in waist circumference and blood glucose, insulin and testosterone levels. Moreover, a statistically significant difference was reported in variations of total Hospital Anxiety and Depression Scale (HADS) score, in the anxiety HADS score and improvement in joint pain. Our results suggested that promoting a healthy lifestyle in clinical practice reduces risk factors involved in BC recurrence and ensures psycho-physical well-being.

【 授权许可】

Unknown