Lovastatin Alleviates α-Synuclein Aggregation and Phosphorylation in Cellular Models of Synucleinopathy

Frontiers in Molecular Neuroscience

Jiannan Wang¹  Lijun Dai¹  Min Xiong¹  Zhentao Zhang¹  Ye Tian¹  Mingyang He²  Chaoyang Liu³ 

[1] Department of Neurology, Renmin Hospital of Wuhan University, Wuhan, China;Hubei Provincial Institute for Food Supervision and Test, Wuhan, China;Research Center for Environment and Health, Zhongnan University of Economics and Law, Wuhan, China;

关键词: Parkinson’s disease;    protein aggregation;    α-synuclein;    statins;    casein kinase 2;    haistone acetylation;   

DOI  :  10.3389/fnmol.2021.682320

来源: DOAJ

【 摘 要 】

Parkinson’s disease (PD) is one of the most common neurodegenerative diseases. Pathologically, it is characterized by the aberrant aggregation of α-synuclein (α-syn) in neurons. Clinical evidence shows that patients with hypercholesterolemia are more likely to get PD, while lovastatin users have a lower risk of suffering from it. In this study, we investigated the effects of lovastatin on the aggregation and phosphorylation of α-syn in vitro. Our results demonstrate that α-syn preformed fibrils induce the phosphorylation and aggregation of α-syn in HEK293 cells stably transfected with α-syn-GFP and SH-SY5Y cells as well, which could be attenuated by in a concentration-dependent manner. Besides, lovastatin inhibited oxidative stress, histone acetylation, and the activation of casein kinase 2 (CK2). Collectively, lovastatin alleviates α-syn aggregation and phosphorylation in cellular models of synucleinopathy, indicating its potential value of being adopted in the management of PD.

【 授权许可】

Unknown