Ultrathin Two‐Dimensional Plasmonic PtAg Nanosheets for Broadband Phototheranostics in Both NIR‐I and NIR‐II Biowindows

Advanced Science

Feng Huang¹  Faisal Saleem²  Zhimin Luo³  Qi Li³  Jinyan Li³  Lianhui Wang³  Yefan Duan³  Panpan He³  Chuang Shen³  Ying Zhang³  Qi Shen³  Jing Wang³ 

[1] Department of Human Anatomy, School of Basic Medical Sciences Key Laboratory of Brain Aging and Neurodegenerative Diseases of Fujian Province Fujian Medical University 1 Xueyuan Road Fuzhou 350122 China;Key Laboratory of Flexible Electronics (KLOFE) & Institute of Advanced Materials (IAM) Nanjing Tech University (NanjingTech) 30 South Puzhu Road Nanjing 211816 China;State Key Laboratory for Organic Electronics and Information Displays and Jiangsu Key Laboratory for Biosensors Institute of Advanced Materials (IAM) Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM) College of Electronic and Optical Engineering and College of Microelectronic Nanjing University of Posts and Telecommunications 9 Wenyuan Road Nanjing 210023 China;

关键词: broadband near‐infrared biowindow;    photoacoustic imaging;    phototheranostics;    photothermal therapy;    PtAg nanosheets;   

DOI  :  10.1002/advs.202100386

来源: DOAJ

【 摘 要 】

Abstract Broadband near‐infrared (NIR) photothermal and photoacoustic agents covering from the first NIR (NIR‐I) to the second NIR (NIR‐II) biowindow are of great significance for imaging and therapy of cancers. In this work, ultrathin two‐dimensional plasmonic PtAg nanosheets are discovered with strong broadband light absorption from NIR‐I to NIR‐II biowindow, which exhibit outstanding photothermal and photoacoustic effects under both 785 and 1064 nm lasers. Photothermal conversion efficiencies (PCEs) of PtAg nanosheets reach 19.2% under 785 nm laser and 45.7% under 1064 nm laser. The PCE under 1064 nm laser is higher than those of most reported inorganic NIR‐II photothermal nanoagents. After functionalization with folic acid modified thiol‐poly(ethylene glycol) (SH‐PEG‐FA), PtAg nanosheets endowed with good biocompatibility and 4T1 tumor‐targeted function give high performances for photoacoustic imaging (PAI) and photothermal therapy (PTT) in vivo under both 785 and 1064 nm lasers. The effective ablation of tumors in mice can be realized without side effects and tumor metastasis by PAI‐guided PTT of PtAg nanosheets under 785 or 1064 nm laser. The results demonstrate that the prepared PtAg nanosheets with ultrathin thickness and small size can serve as a promising phototheranostic nanoplatform for PAI‐guided PTT of tumors in both NIR‐I and NIR‐II biowindows.

【 授权许可】

Unknown