Histone Acetylation and Modifiers in Renal Fibrosis

Frontiers in Pharmacology

Shougang Zhuang¹  Fengchen Shen² 

[1] Department of Medicine, Rhode Island Hospital and Alpert Medical School, Brown University, Providence, RI, United States;Department of Nephrology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China;

关键词: histone acetylation;    histone acetyltransferases;    histone deacetylases;    bromodomain and extraterminal proteins;    renal fibrosis;    epithelial-mesenchymal transition;   

DOI  :  10.3389/fphar.2022.760308

来源: DOAJ

【 摘 要 】

Histones are the most abundant proteins bound to DNA in eukaryotic cells and frequently subjected to post-modifications such as acetylation, methylation, phosphorylation and ubiquitination. Many studies have shown that histone modifications, especially histone acetylation, play an important role in the development and progression of renal fibrosis. Histone acetylation is regulated by three families of proteins, including histone acetyltransferases (HATs), histone deacetylases (HDACs) and bromodomain and extraterminal (BET) proteins. These acetylation modifiers are involved in a variety of pathophysiological processes leading to the development of renal fibrosis, including partial epithelial-mesenchymal transition, renal fibroblast activation, inflammatory response, and the expression of pro-fibrosis factors. In this review, we summarize the role and regulatory mechanisms of HATs, HDACs and BET proteins in renal fibrosis and provide evidence for targeting these modifiers to treat various chronic fibrotic kidney diseases in animal models.

【 授权许可】

Unknown