Cardio-protective and antioxidant properties of caffeic acid and chlorogenic acid: Mechanistic role of angiotensin converting enzyme, cholinesterase and arginase activities in cyclosporine induced hypertensive rats

Biomedicine & Pharmacotherapy

Ganiyu Oboh¹  Temitayo Olabisi Ajibade²  Temidayo Olutayo Omobowale³  Adeolu Alex Adedapo³  Ayokunle Olubode Ademosun⁴  Akintunde Afolabi Akindahunsi⁴  Adedayo Oluwaseun Ademiluyi⁴  Ademola Adetokunbo Oyagbemi⁴  Odunayo Michael Agunloye⁴ 

[1] Corresponding author.;Department of Veterinary Medicine, Faculty of Veterinary Medicine, University of Ibadan, Nigeria;Department of Veterinary Physiology and Biochemistry, Faculty of Veterinary Medicine, University of Ibadan, Nigeria;Functional Foods and Nutraceuticals Unit, Department of Biochemistry, Federal University of Technology, P.M.B 704, Akure 340001, Nigeria;

关键词: Cyclosporine;    Caffeic acid;    Chlorogenic acid;    Blood pressure;    Nitric oxide;   

DOI  :  

来源: DOAJ

【 摘 要 】

Caffeic acid (CAA) and chlorogenic acid (CHA) are important members of hydroxycinnamic acid with natural antioxidant and cardio-protective properties. The present study aimed to determine the effect of CAA and CHA on systolic blood pressure, heart rates (HR) as well as on the activity of the angiotensin-1-converting enzyme (ACE), acetylcholinesterase (AChE), butrylcholinesterase (BChE) and arginase in cyclosporine-induced hypertensive rats. Experimental rats were distributed into 7 groups (n = 6): normotensive control rats; hypertensive rats (induced rats) as well as hypertensive- treated groups with captopril (10 mg/kg/day), CAA (10 and 15 mg/kg/day) and CHA (10 and 15 mg/kg/day), respectively. The experiment lasted for 7 days and the systolic blood pressure (SBP) and heart rates were recorded using tail-cuff method. Oral administration of captopril, caffeic acid and chlorogenic acid normalized hypertensive effect caused by cyclosporine administration. CAA and CHA significantly (P < 0.05) reduced SBP and HR, activity of ACE, AChE, BChE and arginase in the treated hypertensive rats compared with cyclosporine induced-hypertensive rats. Likewise, CAA and CHA improved nitric oxide (NO) bioavailability, increased catalase activity and reduced glutathione content while malondialdehyde (MDA) level was reduced compared with cyclosporine hypertensive rats. Findings from this study shows that CAA and CHA exhibited blood pressure lowering properties and reduced activities of key enzymes linked to the pathogenesis of hypertension in cyclosporine-induced rats. These might be some of the possible mechanisms of action by which their cardio-protective properties are exhibited.

【 授权许可】

Unknown