C-reactive protein, glucose and iron concentrations are significantly altered in dogs undergoing open ovariohysterectomy or ovariectomy

Acta Veterinaria Scandinavica

Marijke Elisabeth Peeters¹  Elena Regine Moldal²  Ane Nødtvedt³  Mads Jens Kjelgaard-Hansen⁴  Jolle Kirpensteijn⁵ 

[1] Department of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, University of Utrecht;Department of Companion Animal Clinical Sciences, Faculty of Veterinary Medicine and Biosciences, Norwegian University of Life Sciences;Department of Production Animal Clinical Sciences, Faculty of Veterinary Medicine and Biosciences, Norwegian University of Life Sciences;Department of Veterinary Clinical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen;Hill’s Pet Nutrition Inc;

关键词: C-reactive protein;    Glucose;    Iron;    Ovariectomy;    Ovariohysterectomy;    Surgery;   

DOI  :  10.1186/s13028-018-0384-6

来源: DOAJ

【 摘 要 】

Abstract Background There are relatively few studies about the canine surgical stress response, a sequence of events orchestrated by the body in response to a surgical trauma which is sometimes, as shown in human surgery, deleterious to the patient. There is a need to identify objective markers to quantify this response in order to estimate tissue trauma and use the markers as potential early indicators of surgical complications. The study objective was to investigate the surgical stress response, measured by C-reactive protein (CRP), glucose and iron serum concentrations, to gonadectomy in female dogs, and to compare the response to ovariohysterectomy (OHE) with the response to ovariectomy (OVE). A randomized clinical trial was performed on a sample of 42 female dogs, which were divided into two groups: one group underwent OHE, the other OVE. Results Blood samples were collected immediately before surgery (T0), and at 1 (T1), 6 (T6), and 24 (T24) h after surgery, and serum frozen and stored at − 80 °C for later analysis. Upon thawing, the serum samples were subjected to measurement of CRP, glucose and iron concentration. Seventeen dogs in the OHE group and 19 dogs in the OVE group were included in the statistical analysis. There was a significant increase in glucose concentration at all time points compared with T0, and an increase of CRP at T6 and T24. Iron concentration was significantly decreased at T6 and T24. Differences between the two groups could not be detected for any of the three variables. Conclusions The study showed that both OHE and OVE induce a moderate surgical stress response in female dogs, measured by CRP, glucose and iron. A difference between the surgical techniques could not be detected for any of the variables, and hence; with regards to the parameters studied recommendations of one procedure over the other cannot be made and preferred technique remains the surgeon’s choice.

【 授权许可】

Unknown