Adherence to the Mediterranean diet assessed by a novel dietary biomarker score and mortality in older adults: the InCHIANTI cohort study

BMC Medicine

Cristina Andres-Lacueva¹  Montserrat Rabassa¹  Nicole Hidalgo-Liberona¹  Tomás Meroño¹  Raul Zamora-Ros¹  Luigi Ferrucci²  Antonio Cherubini³  Stefania Bandinelli⁴  Toshiko Tanaka⁵  Richard Semba⁶ 

[1] Biomarkers and Nutrimetabolomics Laboratory, Department of Nutrition, Food Sciences and Gastronomy, Faculty of Pharmacy and Food Sciences, University of Barcelona;Clinical Research Branch, National Institute on Aging, NIH;Geriatria, Accettazione Geriatrica e Centro di Ricerca per l’invecchiamento, IRCCS INRCA;Geriatric Unit, ASL Toscana Centro;Translational Gerontology Branch, National Institute on Aging, NIH;Wilmer Eye Institute, Johns Hopkins University School of Medicine;

关键词: Dietary biomarkers;    Older adults;    Mediterranean diet;    Mortality;    Polyphenols;    Carotenoids;   

DOI  :  10.1186/s12916-021-02154-7

来源: DOAJ

【 摘 要 】

Abstract Background Dietary biomarkers may complement dietary intake assessment made by dietary questionnaires. We developed an a-posteriori dietary biomarkers score based on Mediterranean diet food groups and evaluated its association with mortality. Methods 642 participants (56% female), aged ≥65 years, with complete data on dietary biomarkers were followed during 20 years in the InCHIANTI cohort study (Tuscany, Italy). The main outcomes were all-cause, cardiovascular, and cancer mortality. Dietary biomarkers were selected from literature and from correlation analyses with dietary intakes of Mediterranean diet food groups in the study. The baseline levels of the following dietary biomarkers were chosen: urinary total polyphenols and resveratrol metabolites, and plasma carotenoids, selenium, vitamin B12, linolenic, eicosapentaenoic and docosahexaenoic acids, and the mono-unsaturated/saturated fatty acid ratio. Associations of the Mediterranean diet score using dietary biomarkers and a validated food frequency questionnaire (FFQ) (as tertiles) with mortality were assessed through Cox regression. Results During the 20-year follow-up [median (Q1–Q3), 14 (8–18) years], and 435 deaths occurred (139 from cardiovascular diseases and 89 from cancer-related causes). In the fully adjusted models, the dietary biomarker-Mediterranean diet score was inversely associated with all-cause (HRT3vs.T1 0.72; 95%CI 0.56–0.91) and cardiovascular (HRT3vs.T1 0.60; 95%CI 0.38–0.93), but not with cancer mortality. Associations between the FFQ-Mediterranean diet score and mortality were not statistically significant. Conclusions A greater adherence at baseline to a Mediterranean diet assessed by a dietary biomarker score was associated with a lower risk of mortality in older adults during a 20-year follow-up. The measurement of dietary biomarkers may contribute to guide individualized dietary counseling to older people. Trial registration NCT01331512

【 授权许可】

Unknown