The Kidney Clock Contributes to Timekeeping by the Master Circadian Clock

International Journal of Molecular Sciences

AmaliaRidla Rahim¹  HughDavid Piggins²  Mei-Yi Wu³  Jihwan Myung⁴  Dean Wu⁴  VuongHung Truong⁴  Chun-Ya Lee⁵  Mai-Szu Wu⁶ 

[1]Shuang Ho Hospital, New Taipei City 23561, Taiwan

[2]Department of Neurology, Shuang Ho Hospital, New Taipei City 23561, Taiwan

[3]Division of Nephrology, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, Taipei 11031, Taiwan

[4]Graduate Institute of Mind, Brain and Consciousness, Taipei Medical University, Taipei 11031, Taiwan

[5]

[6]Laboratory of Braintime, Taipei Medical University, Taipei 11031 &School of Physiology, Pharmacology, and Neuroscience, Faculty of Life Sciences, University of Bristol, Biomedical Sciences Building, University Walk, Bristol BS8 1TD, UK

关键词: circadian clocks;    systemic clocks;    CKD;    kidney;    SCN;    hierarchical organization;   

DOI  :  10.3390/ijms20112765

来源: DOAJ

【 摘 要 】

The kidney harbors one of the strongest circadian clocks in the body. Kidney failure has long been known to cause circadian sleep disturbances. Using an adenine-induced model of chronic kidney disease (CKD) in mice, we probe the possibility that such sleep disturbances originate from aberrant circadian rhythms in kidney. Under the CKD condition, mice developed unstable behavioral circadian rhythms. When observed in isolation in vitro, the pacing of the master clock, the suprachiasmatic nucleus (SCN), remained uncompromised, while the kidney clock became a less robust circadian oscillator with a longer period. We find this analogous to the silencing of a strong slave clock in the brain, the choroid plexus, which alters the pacing of the SCN. We propose that the kidney also contributes to overall circadian timekeeping at the whole-body level, through bottom-up feedback in the hierarchical structure of the mammalian circadian clocks.

【 授权许可】

Unknown