Inhibition of cAMP responsive element binding protein in striatal neurons enhances approach and avoidance responses towards morphine- and morphine withdrawal-related cues

Frontiers in Behavioral Neuroscience

Carles Sanchis-Segura¹  Angel Barco²  Maria Jimenez-Minchan²  Dragana Jancic² 

[1]Universidad Miguel Hernández-Consejo Superior de Investigaciones Científicas

[2]Universitat Jaume I

关键词: Morphine;    Addiction;    CREB;    Place Preference;    dorsal striatum;   

DOI  :  10.3389/neuro.08.030.2009

来源: DOAJ

【 摘 要 】

To investigate the role of cAMP resposive element binding protein (CREB)-dependent gene expression in morphine induced behaviors, we examined bitransgenic mice expressing a dominant and strong inhibitor of the CREB family of transcription factors, A-CREB, in striatal neurons in a regulatable manner. The expression of A-CREB in the striatum enhanced both morphine-induced conditioned place preference and morphine withdrawal–induced conditioned place avoidance. Our experiments thereby support a role for CREB in striatal neurons regulating approach and avoidance responses towards drug-related cues.

【 授权许可】

Unknown