Global Repigmentation Strategy of Grey Hair Follicles by Targeting Oxidative Stress and Stem Cells Protection

Applied Sciences

Daniel Auriol¹  Pascale Auriol¹  Romain Reynaud¹  Amandine Scandolera²  Emilie Chapuis²  MorganeDe Tollenaere² 

[1] Givaudan France SAS, Bâtiment Canal Biotech 1, 3 Rue des Satellites, 31400 Toulouse, France;Givaudan France SAS, Route de Bazancourt, 51110 Pomacle, France;

关键词: canities;    oxidative stress;    hair follicles;    active ingredient;   

DOI  :  10.3390/app11041533

来源: DOAJ

【 摘 要 】

One of the most visible signs of hair ageing is greying of the hair, also known as canities. This hair disorder is mainly caused by oxidative stress. In preliminary work, we designed various models mimicking the impact of oxidative stress on hair pigmentation, showing an accumulation of reactive oxygen species (ROS) production and a decrease in the presence of melanocytes and melanoblasts, resulting in a decrease in hair pigmentation. A proteomic study on skin scalp explants was performed to identify the dysregulated biological pathways related to canities. We developed a smart active ingredient which has been tested on these biological pathways. We demonstrated that these negative effects were rectified in the presence of the ingredient, showing a reduction of ROS, protection of melanocyte reservoirs and reactivation of hair pigmentation. Finally, a clinical study was carried out on a panel of 44 male volunteers with grey hair. After 4 months, we evidenced a reduction in the proportion of grey hair and in the number of grey hairs/cm² relative to Day 0. In conclusion, we clearly evidenced that oxidative stress is a key factor in triggering a cascade of events leading to a loss of hair pigmentation. We developed this active ingredient which is capable of restoring all the disrupted mechanisms and of providing hair repigmentation within only 4 months.

【 授权许可】

Unknown