Intestinal Saturated Long-Chain Fatty Acid, Glucose and Fructose Transporters and Their Inhibition by Natural Plant Extracts in Caco-2 Cells

Molecules

Katharina Schreck¹  MatthiasF. Melzig¹ 

[1] Freie Universitaet Berlin, Institute of Pharmacy-Pharmaceutical Biology, Koenigin-Luise-Str. 2+4, D-14195 Berlin, Germany;

关键词: diabetes;    Caco-2 cells;    plant extracts;    uptake inhibition;    intestinal transporters;    FATP2;    FATP4;    SGLT1;    GLUT2;    GLUT5;   

DOI  :  10.3390/molecules23102544

来源: DOAJ

【 摘 要 】

The intestinal absorption of fatty acids, glucose and fructose is part of the basic requirements for the provision of energy in the body. High access of saturated long-chain fatty acids (LCFA), glucose and fructose can facilitate the development of metabolic diseases, particularly the metabolic syndrome and type-2 diabetes mellitus (T2DM). Research has been done to find substances which decelerate or inhibit intestinal resorption of these specific food components. Promising targets are the inhibition of intestinal long-chain fatty acid (FATP2, FATP4), glucose (SGLT1, GLUT2) and fructose (GLUT2, GLUT5) transporters by plant extracts and by pure substances. The largest part of active components in plant extracts belongs to the group of polyphenols. This review summarizes the knowledge about binding sites of named transporters and lists the plant extracts which were tested in Caco-2 cells regarding uptake inhibition.

【 授权许可】

Unknown