LINC00909 promotes tumor progression in human glioma through regulation of miR-194/MUC1-C axis

Biomedicine & Pharmacotherapy

Chengyin Lu¹  Wei Sun²  Zhentao Liu³  Guohan Hu³  Hongkang Hu³  Zheng Cai³  Qiang Liang³  Lei Jiang³ 

[1] Department of Neurosurgery, 91 Central Hospital of People’s Liberation Army, Jiaozuo Henan Province, 454150, China;Department of Pharmaceutics, Shanghai Changhai Hospital, Second Military Medical University, Shanghai, 200433, China;Department of Neurosurgery, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai, 200003, China;

关键词: Glioma;    LINC00909;    miR-194;    MUC1-C;    ceRNA;   

DOI  :  

来源: DOAJ

【 摘 要 】

Long non‐coding RNAs (lncRNAs) play important roles in tumor progression. Whereas the roles and underlying mechanisms of LINC00909 (a newly discovered lncRNA) are still unclear in glioma progression. In the present study, we identified that LINC00909 expression was significantly elevated in glioma tissues and cell lines. High LINC00909 expression was associated with advanced WHO grade, high Karnofsky Performance Score (KPS), and poor prognosis in patients with glioma. Function assays showed that LINC00909 depletion inhibited glioma cells proliferation, invasion in vitro and reduced tumor growth in vivo. In the mechanism, we found that LINC00909 could act as a ceRNA to interact with miR-194 and thereby up‐regulate the expression of MUC1-C, thus promoting the proliferation and invasion of glioma cells. Collectively, these data demonstrated that LINC00909/miR-194/MUC1-C axis regulated glioma progression and might act as a novel therapeutic target.

【 授权许可】

Unknown