Does Mediterranean Adequacy Index Correlate with Cardiovascular Events in Patients with Advanced Chronic Kidney Disease? An Exploratory Study

Nutrients

Marco Bagnati¹  Roberta Rolla¹  Matteo Vidali²  Andreana De Mauri³  Doriana Chiarinotti³  Sergio Riso⁴  Deborah Carrera⁴  Massimo Torreggiani⁵ 

[1] Clinical Chemistry Laboratory, Maggiore della Carità University Hospital, 28100 Novara, Italy;Clinical Chemistry Unit, Fondazione IRCCS Ca’ Granda Maggiore Policlinico Hospital, 20122 Milano, Italy;Nephrology and Dialysis Unit, Maggiore della Carità University Hospital, 28100 Novara, Italy;Nutritional Science and Dietetic, Maggiore della Carità University Hospital, 28100 Novara, Italy;Néphrologie et Dialyse, Centre Hospitalier Le Mans, 72037 Le Mans, France;

关键词: Mediterranean Adequacy Index;    Mediterranean diet;    chronic kidney disease;    adherence;    p-cresol-sulphate;    indoxyl-sulphate;   

DOI  :  10.3390/nu14091687

来源: DOAJ

【 摘 要 】

The Mediterranean Diet (MD) is a healthy dietary pattern, demonstrated to reduce the risk of cancer, diabetes, cardiovascular and neurodegenerative diseases, and early death. The Mediterranean Adequacy Index (MAI) is used to measure adherence to the MD in perspective studies in the general population and correlates with cardiovascular events. The aim of this study was to calculate the MAI among patients with advanced chronic kidney disease (CKD) and correlate it with traditional uremic, microbiota-derived, and proatherogenic toxins as well as nutritional status, quality of life, and cardiovascular events. A total of 60 adult patients with advanced CKD were enrolled and their MAI was calculated. According to the median value, patients were divided into lower (l-MAI, <1.80) and higher (h-MAI, ≥1.80) MAI groups. Biochemical parameters, microbiota-derived and proatherogenic toxins (p-Cresyl sulphate, Indoxyl-sulphate, and Lipoprotein-associated phospholipase A₂), nutritional status, quality of life, and cardiovascular events that occurred in the previous three years were recorded. The mean value of the MAI was 2.78 ± 2.86. The MAI was significantly higher in foreigners (median (IQR) 6.38 (8.98) vs. 1.74 (1.67), p < 0.001) and diabetic patients. The l-MAI and h-MAI groups had similar routinary blood, p-Cresyl-sulphate, Indoxyl-sulphate, and Lp-PLA₂ as well as nutritional status and quality of life parameters. The MAI was not associated with previous cardiovascular events and did not correlate with cardiovascular events in CKD patients. New and nephro-tailored indexes are warranted to evaluate nutritional therapy in CKD patients.

【 授权许可】

Unknown