Ultrasonographic scoring system score versus liver stiffness measurement in prediction of cirrhosis

Clinical and Molecular Hepatology

Young Woo Eom¹  Kyoung Min Moon²  Moon Young Kim³  Seung Yong Shin³  Jung Min Kim³  Sang Ok Kwon³  Soon Koo Baik³  Hong Jun Park³  Hyoun A Kim³  Gaeun Kim⁴  Mee Yon Cho⁵  Eunhee Choi⁶ 

[1] Cell Therapy and Tissue Engineering Center, Yonsei University Wonju College of Medicine, Wonju, Korea.;Department of Internal Medicine, Konyang University College of Medicine, Daejeon, Korea.;Department of Internal Medicine, Yonsei University Wonju College of Medicine, Wonju, Korea.;Department of Nursing, Keimyung University College of Nursing, Daegu, Korea.;Department of Pathology, Yonsei University Wonju College of Medicine, Wonju, Korea.;Institute of Lifestyle Medicine, Yonsei University Wonju College of Medicine, Wonju, Korea.;

关键词: Ultrasonography;    Elastography;    Cirrhosis;    Biopsy;   

DOI  :  10.3350/cmh.2013.19.4.389

来源: DOAJ

【 摘 要 】

Background/AimsWe compared the cirrhosis-prediction accuracy of an ultrasonographic scoring system (USSS) combining six representative sonographic indices with that of liver stiffness measurement (LSM) by transient elastography, and prospectively investigated the correlation between the USSS score and LSM in predicting cirrhosis.MethodsTwo hundred and thirty patients with chronic liver diseases (187 men, 43 women; age, 50.4±9.5 y, mean±SD) were enrolled in this prospective study. The USSS produces a combined score for nodularity of the liver surface and edge, parenchyma echogenicity, presence of right-lobe atrophy, spleen size, splenic vein diameter, and abnormality of the hepatic vein waveform. The correlations of the USSS score and LSM with that of a pathological liver biopsy (METAVIR scoring system: F0-F4) were evaluated.ResultsThe mean USSS score and LSM were 7.2 and 38.0 kPa, respectively, in patients with histologically overt cirrhosis (F4, P=0.017) and 4.3 and 22.1 kPa in patients with fibrotic change without overt cirrhosis (F0-F3) (P=0.025). The areas under the receiver operating characteristic (ROC) curves of the USSS score and LSM for F4 patients were 0.849 and 0.729, respectively. On the basis of ROC curves, criteria of USSS ≥6: LSM ≥17.4 had a sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of 89.2%:77.6%, 69.4%:61.4%, 86.5%:83.7%, 74.6%:51.9% and 0.83:0.73, respectively, in predicting F4.ConclusionsThe results indicate that this USSS has comparable efficacy to LSM in the diagnosis of cirrhosis.

【 授权许可】

Unknown