Role of Mesenchymal Stem Cells—Derived Exosomes in Osteoarthritis Treatment

Folia Veterinaria

Rosocha J.¹  Ledecký V.²  Kuricová M.²  Ševčík K.²  Hluchý M.²  Huňáková K.² 

[1] Associated Tissue Bank, Faculty of Medicine of P. J. Šafárik University and University Hospital of L. Pasteur, KošiceSlovakia;Small Animal Clinic, University of Veterinary Medicine and Pharmacy Komenského 73, 041 81Košice;

关键词: exosomes;    osteoarthritis;    stem cell;    treatment;   

DOI  :  10.2478/fv-2018-0033

来源: DOAJ

【 摘 要 】

Exosomes are nanovesicles that are involved in inter-cellular communication and are secreted by many types of cells. Exosomes secreted by stem cells can effectively transport bioactive proteins, messenger ribonucleic acids (mRNAs) and microribonucleic acids (miRNAs) organelles and play important roles in intercellular communication and the regulation of tissue regeneration. This transfer of bioactive molecules plays a main role in: tumor invasion and metastasis, immune and inflammation modulation, epithelial-mesenchymal transition and neurobiology. Mesenchymal Stem Cells (MSC) exosomes provide new perspectives for the development of an off-the-shelf and cell-free MSC therapy for the treatment of cartilage injuries and osteoarthritis. This report describes the progress in exosome studies and potential clinical use for osteoarthritis treatment.

【 授权许可】

Unknown