The Effectiveness and Retention Rate of Iguratimod in Japanese Rheumatoid Arthritis Patients with/without Methotrexate in Daily Medical Care

Life

Yasutaka Chiba¹  Yuji Nozaki²  Itaru Matsumura²  Masanori Funauchi²  Koji Kinoshita²  Asuka Inoue³  Yasuaki Hirooka³ 

[1] Department of Clinical Research Center, Kindai University School of Medicine, Osaka 589-8511, Japan;Department of Hematology and Rheumatology, Kindai University School of Medicine, Osaka 589-8511, Japan;Department of Rheumatology, Kindai University Nara Hospital, Nara 630-0293, Japan;

关键词: iguratimod;    methotrexate;    rheumatoid arthritis;    clinical response;    retention rate;   

DOI  :  10.3390/life10110261

来源: DOAJ

【 摘 要 】

(1) Background: We evaluated the clinical response of iguratimod (IGU) in patients with rheumatoid arthritis (RA) being treated with or without methotrexate (MTX) over 54 weeks. (2) Methods: 106 patients with RA undergoing IGU were retrospectively observed. RA patients were divided into those treated with MTX+IGU (n = 35) and those treated with IGU (n = 71). The primary endpoint was the clinical response of the Disease Activity Score assessing 28 joints with C-reactive protein (DAS28-CRP) differences in the changes from baseline to 54 weeks between MTX+IGU and IGU groups. Secondary endpoints, such as the clinical response, retention rate, and safety, were evaluated. (3) Results: The DAS28-CRP difference in the changes between the two groups were −0.2. DAS28-CRP were significantly reduced from the baseline in the MTX+IGU and IGU groups (−1.43 and −1.20 from baseline, respectively). The retention rates were 71.4% in the MTX+IGU groups and 59.2% in the IGU groups (p = 0.16). Adverse events were observed in a total of 6 (17.1%) MTX+IGU patients and 20 (28.2%) IGU patients (p = 0.21). (4) Conclusions: IGU therapy may be a useful treatment option for patients who cannot be treated with MTX.

【 授权许可】

Unknown