Electrochemistry of Graphene Nanoplatelets Printed Electrodes for Cortical Direct Current Stimulation

Frontiers in Neuroscience

Michael Brosch¹  Jakub Krzemiński²  Małgorzata Jakubowska²  Robert Ziółkowski³  Sanchit Rathi⁴  Daniel Janczak⁵  Andrzej Pepłowski⁵  Bartosz Piotrkowski⁵ 

[1] Center for Behavioral Brain Sciences, Otto von Guericke University, Magdeburg, Germany;Centre for Advanced Materials and Technologies, Warsaw University of Technology, Warsaw, Poland;Chair of Medical Biotechnology, Faculty of Chemistry, Warsaw University of Technology, Warsaw, Poland;Faculty of Electrical Engineering and Information Technology, Otto von Guericke University, Magdeburg, Germany;Institute of Metrology and Biomedical Engineering, Faculty of Mechatronics, Warsaw University of Technology, Warsaw, Poland;Research Group Comparative Neuroscience, Leibniz Institute for Neurobiology, Magdeburg, Germany;

关键词: flexible electrodes;    graphene nanoplatelets;    neural stimulation;    voltammetry;    screen-printing;   

DOI  :  10.3389/fnins.2020.594235

来源: DOAJ

【 摘 要 】

Possible risks stemming from the employment of novel, micrometer-thin printed electrodes for direct current neural stimulation are discussed. To assess those risks, electrochemical methods are used, including cyclic voltammetry, square-wave voltammetry, and electrochemical impedance spectroscopy. Experiments were conducted in non-deoxidized phosphate-buffered saline to better emulate living organism conditions. Since preliminary results obtained have shown unexpected oxidation peaks in 0–0.4 V potential range, the source of those was further investigated. Hypothesized redox activity of printing paste components was disproven, supporting further development of proposed fabrication technology of stimulating electrodes. Finally, partial permeability and resulting electrochemical activity of underlying silver-based printed layers of the device were pointed as the source of potential tissue irritation or damage. Employing this information, electrodes with corrected design were investigated, yielding no undesired redox processes.

【 授权许可】

Unknown