Effect of dabai (Canarium odontophyllum) fruit extract on biochemical parameters of induced obese–diabetic rats

Journal of Functional Foods

Azrina Azlan¹  Muhajir Hamid²  Amin Ismail³  Fouad Abdulrahman Hassan³  Nurul Nadirah Mokiran³ 

[1] Corresponding author. Tel.: [phone];fax: [phone].;Centre of Research for Nutrition and Non-communicable Diseases, Department of Nutrition and Dietetics, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia;

关键词: Dabai;    Obese-diabetic;    Polyphenol compounds;    Glucose;    Insulin;    Lipid profile;   

DOI  :  

来源: DOAJ

【 摘 要 】

Dabai is one of the most popular indigenous fruits in Sarawak, and is rich in various nutrients. In this study, the effect of dabai fruit extract (300 and 600 mg/kg bw) on the biochemical parameters of obese–diabetic (Ob-db) rats was investigated. After a 4-week treatment period, the dabai extract at a concentration of 600 mg/kg bw (equivalent to 20 g of flesh with skin of fresh fruit) showed a pronounced effect in lowering the plasma glucose level compared with 300 mg extract/kg bw (equivalent to 10 g of flesh with skin of fresh fruit). The dabai extract also significantly reduced the plasma cholesterol and low-density lipoprotein (LDL-c) levels and increased high-density lipoprotein (HDL-c). However, the dabai extract did not increase the insulin level but did increase its sensitivity and reduced insulin resistance (HOMA-IR). This study suggests that dabai extract possesses hypocholesterolaemic properties, has a short-term glucose-lowering effect and improves the lipid profile through synergistic effect of various polyphenols.

【 授权许可】

Unknown