Role of VEGF Polymorphisms in the Susceptibility and Severity of Interstitial Lung Disease

Biomedicines

Sonia María Fernández Rozas¹  Leticia Lera-Gómez¹  Raquel López-Mejías¹  Víctor Manuel Mora Cuesta¹  Belén Atienza-Mateo¹  Miguel Ángel González-Gay¹  Fernanda Genre¹  Sara Remuzgo-Martínez¹  David Iturbe Fernández¹  Verónica Pulito-Cueto¹  Pilar Alonso Lecue¹  José Manuel Cifrián¹  Alicia De Pablo Gafas²  Virginia Pérez²  Amparo Solé³  María Piedad Ussetti⁴  Rosalía Laporta⁴  Cristina Berastegui⁵  Oreste Gualillo⁶ 

[1] Genetic Epidemiology and Atherosclerosis in Systemic Diseases and in Metabolic Bone Diseases of the Musculoskeletal System, IDIVAL, 39011 Santander, Spain;Lung Transplant Unit, Division of Pulmonology, Hospital Universitario 12 de Octubre, 28041 Madrid, Spain;Lung Transplant and Cystic Fibrosis Unit, Hospital Universitario y Politécnico la Fe, 46026 Valencia, Spain;Pneumology Department, Hospital Universitario Puerta de Hierro, 28222 Majadahonda, Spain;Pneumology Department, Hospital Universitario Vall d´Hebron, Universidad Autónoma de Barcelona, 08035 Barcelona, Spain;SERGAS (Servizo Galego de Saude) and IDIS (Instituto de Investigación Sanitaria de Santiago), NEIRID Lab (Neuroendocrine Interactions in Rheumatology and Inflammatory Diseases), Research Laboratory 9, Santiago University Clinical Hospital, 15706 Santiago de Compostela, Spain;

关键词: interstitial lung disease;    idiopathic interstitial pneumonia;    vascular endothelial growth factor;    biomarker;    genetics;   

DOI  :  10.3390/biomedicines9050458

来源: DOAJ

【 摘 要 】

The search for biomarkers that can help to establish an early diagnosis and prognosis of interstitial lung disease (ILD) is of potential interest. VEGF polymorphisms have been implicated in the development of several lung disorders. Consequently, we assessed, for the first time, the role of VEGF polymorphisms in the susceptibility and severity of ILD. A total of 436 Caucasian ILD patients (244 with idiopathic interstitial pneumonias (IIPs) and 192 with non-IIP) and 536 ethnically-matched healthy controls were genotyped for VEGF rs833061, rs1570360, rs2010963, rs3025020, and rs3025039 polymorphisms by TaqMan assays. Pulmonary function tests were collected from all the patients. VEGF serum levels were determined by ELISA in a subgroup of patients. No VEGF genotype, allele, carrier, or haplotype differences were found between ILD patients and controls as well as between IIP and non-IIP patients. However, an association of rs1570360 with IIP in women and also with lung function in IIP patients was found. None of the VEGF polymorphisms were associated with VEGF levels. In conclusion, our results suggest that VEGF does not seem to play a relevant role in ILD, although rs1570360 may influence the severity of ILD in women and a worse outcome in IIP patients.

【 授权许可】

Unknown