Chronic Kidney disease and stroke: A Bi-directional risk cascade and therapeutic update

Brain Disorders

Bipin Chaurasia¹  Harsh Deora²  Giuseppe Emmanuele Umana³  Vishal Chavda⁴ 

[1] Corresponding author.;Department of Neurosurgery, Bhawani hospital and Research Centre, Birgunj, Nepal;Department of Neurosurgery, National Institute of Mental Health and Neurosciences, Bangalore, India;Division of Anaesthesia, Sardar Women's Hospital, Ahmedabad, Gujarat-India;

关键词: Chronic Kidney disease;    Ischemia;    Translational research;    Anti-platelet therapy;   

DOI  :  

来源: DOAJ

【 摘 要 】

Chronic kidney disease causes a myriad of changes in the normal physiology of the body. Inflammation, atherosclerosis, vascular calcification, the effect of uremic toxins, cerebral blood flow dysautoregulation, dialysis techniques, vascular access, prothrombotic tendency, and anticoagulation are just some of the changes which form a part of the cascade. Stroke is intimately associated with this disease process and it is difficult to manage both simultaneously. In this review, we have narrated to outline the pathophysiological cascade behind each of the two disease processes that how they interact with each other. In this review we have focused on possible therapeutic options exist to manage both with special emphasis on antiplatelets, miRNA, and pre and probiotics. This review exist all the possible pathological pathways and therapeutic targets in such dual cascade that will be very useful for the clinicians while dealing in this complex interplay.

【 授权许可】

Unknown