Evaluation of direct pulp capping with a syntheticchalcone: a preliminary histological study.

Journal of Oral Research

David Tames¹  Xana Ortolan¹  Fátima de Campos-Buzzi¹  Maria Carpeggiani¹  Bruna Tanello¹  Rogério Corrêa¹  Telmo Mezadri¹ 

[1] University of Vale do Itajaí (UNIVALI), Itajaí. Santa Catarina, Brazil;

关键词: Chalcone;    Dental pulp capping;    Wistar rats.;   

DOI  :  10.17126/joralres.2015.040

来源: DOAJ

【 摘 要 】

The aim of this study is to evaluate the action of the synthetic chalcone 1-phenyl-3-(4-chlorophenyl)-2-propen-1-one to induce pulp healing in rats. Material and Methods: Sixty lower first molars of male Wistar rats were divided into 3 groups (n=20): control (no treatment); calcium hydroxide and chalcone. After relative isolation, the cavities were prepared using a sterile low-speed ¼ round dental bur. After controlling the hemorrhaging, all the pulp exposures were capped with the capping material, by groups. The cavities were sealed with glass ionomer cement and the repair process was assessed at 21 days of procedure. The data were statistically analyzed using the Fisher exact test (p<0.05). Results: Moderate inflammation was observed in all the experimental groups and significant (p<0.05) reparative dentin (tertiary) formation in the calcium hydroxide and chalcone groups. The chalcone group showed dentinal tubules and a low number of cellular inclusions (p<0.05). Conclusion: The chalcone used in this study indicates potential as an inducer of reparative dentine (tertiary) in a rat model.

【 授权许可】

Unknown