Precise engineering of cetuximab encapsulated gadollium nanoassemblies: in vitro ultrasound diagnosis and in vivo thyroid cancer therapy

Drug Delivery

Shufeng Gao¹  Ke Wang²  Lingling Guo²  Ming Qi²  Sihui Nie² 

[1] Functional Division, Jinzhou Yixian People’s Hospital;Ultrasound Department, The First Affiliated Hospital of Jinzhou Medical University;

关键词: gadolium nanoassembly;    thyroid cancer;    apoptosis;    ultrasound diagnosis;    in vivo antitumor efficacy;   

DOI  :  10.1080/10717544.2021.1889721

来源: DOAJ

【 摘 要 】

We report the formulation of nanoassemblies (NAs) comprising C225 conjugates Gd-PFH-NAs (C-Gd-PFH-NAs) for low-intensity focused ultrasound diagnosis ablation of thyroid cancer. C-Gd-PFH-NAs showed excellent stability in water, phosphate-buffered saline (PBS), and 20% rat serum. Transmission electron microscopy (TEM) images also revealed the effective construction of C-Gd-PFH-NAs as common spherical assemblies. The incubation of C625 thyroid carcinoma with C-Gd-PFH-NAs triggers apoptosis, as confirmed by flow cytometry analysis. The C-Gd-PFH-NAs exhibited antitumor efficacy in human thyroid carcinoma xenografts, where histopathological results further confirmed these outcomes. Furthermore, we were able to use low-intensity focused ultrasound diagnosis imaging (LIFUS) to examine the efficiency of C-Gd-PFH-NAs in thyroid carcinoma in vivo. These findings clearly show that the use of LIFUS agents with high performance imaging in different therapeutic settings will have extensive potential for future biomedical applications.

【 授权许可】

Unknown