Large-Area Coating of Previtamin D3 Based on Roll-to-Roll Processing

Coatings

Janghoon Park¹  Yoonki Min¹  Jongsu Lee¹  Hakyung Jeong¹  Youngwook Noh¹  Dongjin Lee²  Kee-Hyun Shin² 

[1] Department of Mechanical Design and Production Engineering, Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul 05029, Korea;School of Mechanical Engineering, Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul 05029, Korea;

关键词: slot-die coating;    roll-to-roll (R2R);    vitamin D₃;    ultraviolet B (UVB);    high-performance liquid chromatography (HPLC);   

DOI  :  10.3390/coatings9090577

来源: DOAJ

【 摘 要 】

We propose a roll-to-roll process for vitamin D₃ patch production. A solution of 7-dehydrocholesterol is applied to a plastic film by roll-to-roll slot-die coating and dried by a far-infrared lamp. Upon exposure to ultraviolet B irradiation, these films are converted to previtamin D₃ films. After heat-treating the previtamin D₃ film, high-performance liquid chromatography measurements are performed using commercial vitamin D₃ as a standard sample. The results confirm that vitamin D₃ can be produced by large-area coating and post-treatment processes. Specifically, 3.16 ± 0.746 mg of vitamin D₃ is obtained through ultraviolet B irradiation and heat-treatment of 24.8 ± 1.44 mg of coated 7-dehydrocholesterol.

【 授权许可】

Unknown