Multimodal intervention in older adults improves resting-state functional connectivity between the medial prefrontal cortex and medial temporal lobe

Frontiers in Aging Neuroscience

Shufei eYin¹  Xin eHuang¹  Xinyi eZhu¹  Zhiwei eZheng¹  Rui eLi¹  Yanan eNiu¹  Baoxi eWang¹  Juan eLi¹ 

[1] Institute of Psychology, Chinese Academy of Sciences;

关键词: Aging;    fMRI;    plasticity;    functional connectivity;    intervention;   

DOI  :  10.3389/fnagi.2014.00039

来源: DOAJ

【 摘 要 】

The prefrontal cortex and medial temporal lobe are particularly vulnerable to the effects of aging. The disconnection between them is suggested to be an important cause of cognitive decline in normal aging. Here, using multimodal intervention training, we investigated the functional plasticity in resting-state connectivity of these two regions in older adults. The multimodal intervention, comprised of cognitive training, Tai Chi exercise, and group counseling, was conducted to explore the regional connectivity changes in the default-mode network, as well as changes in prefrontal-based voxel-wise connectivity in the whole brain. Results showed that the intervention selectively affected resting-state functional connectivity between the medial prefrontal cortex and medial temporal lobe. Moreover, the strength of resting-state functional connectivity between these regions correlated with individual cognitive performance. Our results suggest that multimodal intervention could postpone the effects of aging and improve the function of the regions that are most heavily influenced by aging, as well as play an important role in preserving the brain and cognition during old age.
Clinical Trial Registration: This trial was registered in the Chinese Clinical Trial Registry (ChiCTR) (http://www.chictr.org): ChiCTR-PNRC-13003813.

【 授权许可】

Unknown