Imaging and Molecular Mechanisms of Alzheimer’s Disease: A Review

International Journal of Molecular Sciences

Klara Komici¹  Graziamaria Corbi¹  Nicola Ferrara²  Giuseppe Rengo²  Tony Thayanandan³  Valeria Calsolaro⁴  GraziaDaniela Femminella⁴ 

[1] Department of Medicine and Health Sciences, University of Molise, 86100 Campobasso, Italy;Department of Translational Medical Sciences, Federico II University of Naples, 80131 Naples, Italy;Imperial Memory Unit, Charing Cross Hospital, Imperial College London, London W6 8RF, UK;Neurology Imaging Unit, Imperial College London, London W12 0NN, UK;

关键词: Alzheimer’s disease;    positron emission tomography (PET);    magnetic resonance imaging (MRI);   

DOI  :  10.3390/ijms19123702

来源: DOAJ

【 摘 要 】

Alzheimer’s disease is the most common form of dementia and is a significant burden for affected patients, carers, and health systems. Great advances have been made in understanding its pathophysiology, to a point that we are moving from a purely clinical diagnosis to a biological one based on the use of biomarkers. Among those, imaging biomarkers are invaluable in Alzheimer’s, as they provide an in vivo window to the pathological processes occurring in Alzheimer’s brain. While some imaging techniques are still under evaluation in the research setting, some have reached widespread clinical use. In this review, we provide an overview of the most commonly used imaging biomarkers in Alzheimer’s disease, from molecular PET imaging to structural MRI, emphasising the concept that multimodal imaging would likely prove to be the optimal tool in the future of Alzheimer’s research and clinical practice.

【 授权许可】

Unknown