Higher Physical Activity is Associated with Increased Attentional Network Connectivity in the Healthy Elderly

Frontiers in Aging Neuroscience

Kiho Im¹  Sue J. Kang²  Geon Ha Kim³  Jee Hyang Jeong⁴  Young Noh⁵  Hanna Cho⁶  Jong Min Lee⁷  Hunki Kwon⁷  Jung Won Hwang⁹  Hojeong Kim⁹  Sang Eon Park⁹  Sang Won Seo⁹  Duk L. Na⁹  Sung Tae Kim^1,10  Byoung Seok Ye^1,12 

[1] Boston Children’s Hospital, Harvard Medical School;College of Nursing, the Research Institute of Nursing Science,Seoul National University;Ewha Brain Institute, Ewha Womans University;Ewha Womans University Mokdong Hospital, Ewha Womans University School of Medicine;Gachon University Gil Medical Center;Gangnam Severance Hospital, Yonsei University College of Medicine;Hanyang University;Neuroscience Center, Samsung Medical Center;SAIHST, Sungkyunkwan University;Samsung Medical Center, Sungkyunkwan University School of Medicine;Samsung Medical Center;Yonsei University College of Medicine;

关键词: Attention;    physical activity;    brain network;    graph analysis;    Healthy elderly;   

DOI  :  10.3389/fnagi.2016.00198

来源: DOAJ

【 摘 要 】

The purpose of this study was to demonstrate the potential alterations in structural network properties related to physical activity (PA) in healthy elderly. We recruited 76 elderly individuals with normal cognition from Samsung Medical Center in Seoul, Korea. All participants underwent the Cambridge Neuropsychological Test Automated Battery and 3.0T brain magnetic resonance imaging (MRI). Participants were subdivided into quartiles according to the International Physical Activity Questionnaire scores, which represents the amount of PA. Through graph theory based analyses, we compared global and local network topologies according to PA quartile. The higher PA group demonstrated better performance in speed processing compared to the lower PA group. Regional nodal strength also significantly increased in the higher PA group, which involved the bilateral middle frontal, bilateral inferior parietal, right medial orbitofrontal, right superior and middle temporal gyri. These results were further replicated when the highest and the lowest quartile groups were compared in terms of regional nodal strengths and local efficiency. Our findings that the regional nodal strengths associated with the attentional network were increased in the higher PA group suggest the preventive effects of PA on age-related cognitive decline, especially in attention.

【 授权许可】

Unknown