Implantable nerve guidance conduits: Material combinations, multi-functional strategies and advanced engineering innovations

Bioactive Materials

Gang Li¹  Ruotong Yao²  Lirong Duan³  Yi Li⁴  Kaili Chen⁵  Tian Wang⁵  Yixin Yan⁵  Zhaozhu Zheng⁵  Jingyuan Zhao⁵  Zekun Liu⁵  Xiaoqin Wang⁵  Jinping Guan⁶  Shujun Zhang⁷ 

[1] Corresponding author.;Department of Materials, University of Manchester, Oxford Road, Manchester, M13 9PL, UK;Department of Materials, Imperial College London, SW7 2AZ, UK;Department of Materials, University of Manchester, Oxford Road, Manchester, M13 9PL, UK;National Engineering Laboratory for Modern Silk, College of Textile and Clothing Engineering, Soochow University, Suzhou, 215123, China;Research Centre of Printed Flexible Electronics, School of Materials Science and Engineering, Harbin Institute of Technology, Shenzhen, 518055, China;Wilson College of Textiles, North Carolina State University, Raleigh, 27695, USA;

关键词: Nerve guidance conduits;    Micro-nanofibers;    Multi-functional;    Surface modification;    Microenvironment;   

DOI  :  

来源: DOAJ

【 摘 要 】

Nerve guidance conduits (NGCs) have attracted much attention due to their great necessity and applicability in clinical use for the peripheral nerve repair. Great efforts in recent years have been devoted to the development of high-performance NGCs using various materials and strategies. The present review provides a comprehensive overview of progress in the material innovation, structural design, advanced engineering technologies and multi functionalization of state-of-the-art nerve guidance conduits NGCs. Abundant advanced engineering technologies including extrusion-based system, laser-based system, and novel textile forming techniques in terms of weaving, knitting, braiding, and electrospinning techniques were also analyzed in detail. Findings arising from this review indicate that the structural mimetic NGCs combined with natural and synthetic materials using advanced manufacturing technologies can make full use of their complementary advantages, acquiring better biomechanical properties, chemical stability and biocompatibility. Finally, the existing challenges and future opportunities of NGCs were put forward aiming for further research and applications of NGCs.

【 授权许可】

Unknown