Clinico-morphological characteristics of patients with systemic scleroderma before and after autologous bone marrow-derived mesenchymal stem cells transplantation

Ķazaķstannyṇ Klinikalyķ Medicinasy

Manarbek Askarov¹  Natalya Krivoruchko²  Aigerim Imanberdiyeva²  Saltanat Tuganbekovа²  Galiya Shaimardanova³  Galina Fedotovskikh⁴ 

[1] Cellular Technologies and Transplantation Center, National Scientific Medical Center, Astana, Republic of Kazakhstan;No 4 Therapy Department, National Scientific Medical Center, Astana, Republic of Kazakhstan;Scientific Research Management Department, National Scientific Medical Center, Astana, Republic of Kazakhstan;Scientific and Research Laboratory, National Scientific Medical Center, Astana, Republic of Kazakhstan;

关键词: systemic scleroderma;    fibrosis;    skin flap;    mesenchymal stem cells;    bone marrow transplantation;   

DOI  :  10.23950/1812-2892-JCMK-00550

来源: DOAJ

【 摘 要 】

The article describes the clinical and morphological dynamics of systemic scleroderma diffuse form on the background of autologous bone marrow mesenchymal stem cells transplantation. The basis for the mesenchymal stem cells transplantation was the presence of a high activity index of the autoimmune process (EScSG), expressed diffuse skin changes (dense edema, induration) and resistance to immunosuppressive therapy. Transplantation of autologous bone marrow cells at systemic scleroderma contributes clinically to a significant reduction or cupping of skin induration, Raynaud’s syndrome, improvement of patient’s quality of life; morphological decrease of excessive fibrous tissue, stimulation of angiogenesis, and restoration of skin epithelium.

【 授权许可】

Unknown