Expression of LONP1 Is High in Visceral Adipose Tissue in Obesity, and Is Associated with Glucose and Lipid Metabolism

Endocrinology and Metabolism

Hyun Jin Kim¹  Minho Shong¹  Hyon-Seung Yi¹  Bon Jeong Ku¹  Ju Hee Lee¹  Yea Eun Kang¹  Ki Hwan Lee²  Young Bok Ko²  Seul Gi Kang³  Jung Tae Kim³  Ji Eun Kim³  Saet-Byel Jung³  Seong Eun Lee³ 

[1] Department of Internal Medicine, Chungnam National University College of Medicine, Daejeon, Korea;Department of Obstetrics and Gynecology, Chungnam National University College of Medicine, Daejeon, Korea;Research Center for Endocrine and Metabolic Diseases, Chungnam National University College of Medicine, Daejeon, Korea;

关键词: intra-abdominal fat;    obesity;    metabolic syndrome;   

DOI  :  10.3803/EnM.2021.1023

来源: DOAJ

【 摘 要 】

Background The nature and role of the mitochondrial stress response in adipose tissue in relation to obesity are not yet known. To determine whether the mitochondrial unfolded protein response (UPRmt) in adipose tissue is associated with obesity in humans and rodents. Methods Visceral adipose tissue (VAT) was obtained from 48 normoglycemic women who underwent surgery. Expression levels of mRNA and proteins were measured for mitochondrial chaperones, intrinsic proteases, and components of electron-transport chains. Furthermore, we systematically analyzed metabolic phenotypes with a large panel of isogenic BXD inbred mouse strains and Genotype-Tissue Expression (GTEx) data. Results In VAT, expression of mitochondrial chaperones and intrinsic proteases localized in inner and outer mitochondrial membranes was not associated with body mass index (BMI), except for the Lon protease homolog, mitochondrial, and the corresponding gene LONP1, which showed high-level expression in the VAT of overweight or obese individuals. Expression of LONP1 in VAT positively correlated with BMI. Analysis of the GTEx database revealed that elevation of LONP1 expression is associated with enhancement of genes involved in glucose and lipid metabolism in VAT. Mice with higher Lonp1 expression in adipose tissue had better systemic glucose metabolism than mice with lower Lonp1 expression. Conclusion Expression of mitochondrial LONP1, which is involved in the mitochondrial quality control stress response, was elevated in the VAT of obese individuals. In a bioinformatics analysis, high LONP1 expression in VAT was associated with enhanced glucose and lipid metabolism.

【 授权许可】

Unknown