Whole-Genome Analyses Reveal Genomic Characteristics and Selection Signatures of Lincang Humped Cattle at the China–Myanmar Border

Frontiers in Genetics

Xiaohui Ma¹  Bizhi Huang²  Kaixing Qu²  Jicai Zhang²  Quratulain Hanif³  Luyang Sun³  Chuzhao Lei³  Jianyong Liu⁴  Ningbo Chen⁵  Quji Suolang⁵ 

[1] Academy of Science and Technology, Chuxiong Normal University, Chuxiong, China;F University, Yangling, China;;Key Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&National Institute for Biotechnology and Genetic Engineering, Faisalabad, Pakistan;Yunnan Academy of Grassland and Animal Science, Kunming, China;

关键词: whole-genome resequencing;    Lincang humped cattle;    genetic characteristics;    selection signatures;    HELB;   

DOI  :  10.3389/fgene.2022.833503

来源: DOAJ

【 摘 要 】

The location on the Yunnan border with Myanmar and its unique cultural landscape has shaped Lincang humped cattle over time. In the current study, we investigated the genetic characteristics of 22 Lincang humped cattle using whole-genome resequencing data. We found that Lincang humped cattle derived from both Indian indicine and Chinese indicine cattle depicted higher levels of genomic diversity. Based on genome-wide scans, candidate genomic regions were identified that were potentially involved in local thermal and humid environmental adaptions, including genes associated with the body size (TCF12, SENP2, KIF1C, and PFN1), immunity (LIPH, IRAK3, GZMM, and ELANE), and heat tolerance (MED16, DNAJC8, HSPA4, FILIP1L, HELB, BCL2L1, and TPX2). Missense mutations were detected in candidate genes IRAK3, HSPA4, and HELB. Interestingly, eight missense mutations observed in the HELB gene were specific to the indicine cattle pedigree. These mutations may reveal differences between indicine and taurine cattle adapted to variable climatic conditions. Our research provides new insights into the genetic characteristics of Lincang humped cattle representing Lincang and Pu’er areas as an important channel for the migration of Indian indicine from domestication centers toward southwestern China.

【 授权许可】

Unknown