Ethylicin Prevents Potato Late Blight by Disrupting Protein Biosynthesis of Phytophthora infestans

Pathogens

A.Rehman Khalid¹  Linxuan Li²  Yang Chen³  Hanyan Wang⁴  Meiquan Zhang⁵  Shumin Zhang⁵  Pan Dong⁵  Maozhi Ren⁵ 

[1] Department of Plant Pathology, University of Poonch Rawalakot AJK, Rawalakot AJK 12350, Pakistan;Institute of Urban Agriculture, Chinese Academy of Agricultural Sciences, Chengdu 610000, China;Research Center for Atmospheric Environment, Chongqing Institute of Green and Intelligent Technology, Chinese Academy of Sciences, Chongqing 400714, China;School of Basic Medical Sciences, North Sichuan Medical College, Nanchong 637000, China;School of Life Sciences, Chongqing University, Chongqing 401331, China;

关键词: Phytophthora infestans;    ethylicin;    potato late blight;    proteomics;    ribosome;    metabonomics;   

DOI  :  10.3390/pathogens9040299

来源: DOAJ

【 摘 要 】

Phytophthora infestans, the causal agent of potato late blight, triggered the devastating Great Irish Famine that lasted from 1845 to 1852. Today, it is still the greatest threat to the potato yield. Ethylicin is a broad-spectrum biomimetic-fungicide. However, its application in the control of Phytophthora infestans is still unknown. In this study, we investigated the effects of ethylicin on Phytophthora infestans. We found that ethylicin inhibited the mycelial growth, sporulation capacity, spore germination and virulence of Phytophthora infestans. Furthermore, the integrated analysis of proteomics and metabolomics indicates that ethylicin may inhibit peptide or protein biosynthesis by suppressing both the ribosomal function and amino acid metabolism, causing an inhibitory effect on Phytophthora infestans. These observations indicate that ethylicin may be an anti-oomycete agent that can be used to control Phytophthora infestans.

【 授权许可】

Unknown