Angiotensins and rheumatoid arthritis

Научно-практическая ревматология

A. V. Gordeev¹  N. V. Demidova¹  N. M. Savushkina¹  E. A. Galushko¹ 

[1] V.A. Nasonova Research Institute of Rheumatology.;

关键词: renin-angiotensin system;    angiotensins;    angiotensin-converting enzyme inhibitors;    angiotensin receptor blockers;    inflammation;    rheumatoid arthritis;   

DOI  :  10.14412/1995-4484-2018-753-759

来源: DOAJ

【 摘 要 】

At present, the role of the renin-angiotensin system (RAS) in regulating the cardiovascular system and maintaining water and electrolyte homeostasis has been well studied. However, over the past decades, new components of the RAS have been identified, suggesting a wider range of its potential effects on the body. It is of fundamentally importance for rheumatologists to affect inflammation, including rheumatoid inflammation, through blockade of angiotensin (AT) II formation via the effects of AT 1–7 and angiotensin-converting enzyme inhibitors, as well as through suppression of angiogenesis, primarily by reducing the production of endothelial growth factor. The organ-protective and antiinflammatory potential of drugs that reduce the production of AT, which has been proven in in vitro and in vivo experiments, allows us to consider them as first-line angiotropic agents in patients with rheumatoid arthritis, especially in the presence of concomitant hypertension and/or nephropathy.

【 授权许可】

Unknown