Expression of DNA-damage response and repair genes after exposure to DNA-damaging agents in isogenic head and neck cells with altered radiosensitivity

Radiology and Oncology

Prevc Ajda¹  Zakelj Martina Niksic¹  Cemazar Maja¹  Todorovic Vesna¹  Sersa Gregor¹  Groselj Blaz²  Strojan Primoz² 

[1] Department of Experimental Oncology, Institute of Oncology Ljubljana, Ljubljana, Slovenia;Department of Radiation Oncology, Institute of Oncology Ljubljana, Ljubljana, Slovenia;

关键词: head and neck cancer;    squamous cell carcinoma;    radioresistance;    irradiation;    dna-damaging agents;    gene expression profiles;   

DOI  :  10.2478/raon-2022-0014

来源: DOAJ

【 摘 要 】

Increased radioresistance due to previous irradiation or radiosensitivity due to human papilloma virus (HPV) infection can be observed in head and neck squamous cell carcinoma (HNSCC). The DNA-damage response of cells after exposure to DNA-damaging agents plays a crucial role in determining the fate of exposed cells. Tightly regulated and interconnected signaling networks are activated to detect, signal the presence of and repair the DNA damage. Novel therapies targeting the DNA-damage response are emerging; however, an improved understanding of the complex signaling networks involved in tumor radioresistance and radiosensitivity is needed.

【 授权许可】

Unknown