Advances in the genetic basis of ischemic stroke

Journal of Medical Biochemistry

Majkić-Singh Nada¹  Stanković Sanja¹ 

[1] Institute for Medical Biochemistry, University School of Pharmacy and Clinical Center of Serbia, Belgrade;

关键词: allele;    candidate genes;    ischemic stroke;    polymorphism;   

DOI  :  

来源: DOAJ

【 摘 要 】

As one of the leading causes of death within both the developed and developing world, stroke is a worldwide problem. About 80% of strokes are ischemic. It is caused by multiple genetic factors, environmental factors, and interactions among these factors. There is a long list of candidate genes that have been studied for a possible association with ischemic stroke. Among the most widely investigated genes are those involved in haemostasis, inflammation, nitric oxide production, homocysteine and lipid metabolism, renin-angiotensin-aldosterone system. Combined linkage/ association studies have demonstrated that genes encoding PDE4D and ALOX5AP confer risk for stroke. We review the studies of these genes which may have potential application on the early diagnosis, prevention and treatment ischemic stroke patients.

【 授权许可】

Unknown