An inulin-type fructan isolated from Artemisia japonica and its anti-arthritic effects

Journal of Functional Foods

Shunchun Wang¹  Huijun Wang²  Chenchen Shi²  Songshan Shi²  Ning Li²  Jun Yan² 

[1] Corresponding author.;The MOE Key Laboratory for Standardization of Chinese Medicines and the SATCM Key Laboratory for New Resources and Quality Evaluation of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai 201203, PR China;

关键词: Artemisia japonica;    Polysaccharide;    Structure;    Inulin;    Anti-arthritic;   

DOI  :  

来源: DOAJ

【 摘 要 】

Inulin is a type of polysaccharide with nutritional and functional properties and possesses various bioactivities. In this study, we isolated and purified a water-soluble polysaccharide (MWP) from Artemisia japonica. MWP has a molecular weight of 3.1 kDa as calculated by High Performance Gel Permeation Chromatography (HPGPC) and is comprised of fructose and glucose. Methylation analysis, infrared spectroscopy (IR) and nuclear magnetic resonance (NMR) spectra demonstrated that MWP is a typical inulin-type fructan. Oral administration of MWP (200 mg/kg) significantly attenuated the clinical parameters of collagen-induced arthritis (CIA) in DBA/1 mice compared with untreated mice, and a histopathologic analysis indicated less joint damage and inflammatory cell infiltration in mice treated with MWP. The anti-arthritic effects of MWP were associated with reduced serum levels of the interleukins IL-17A and IL-6. These results demonstrate that MWP significantly reduced symptoms in CIA mice and suggest that inulin would be a valuable anti-arthritic agent warranting further investigation.

【 授权许可】

Unknown