Polyphenol Intake and Epithelial Ovarian Cancer Risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) Study

Antioxidants

Rosario Tumino¹  Domenico Palli²  José María Huerta³  Aurelio Barricarte³  Pilar Amiano³  Annika Idahl⁴  Fulvio Ricceri⁵  Maria Santucci de Magistris⁶  Inger T. Gram⁷  Charlotta Rylander⁷  Guri Skeie⁷  Matthias Schulze⁸  Anders Esberg⁹  Kim Overvad^1,10  Hanna Sartor^1,11  Renée Turzanski-Fortner^1,12  Verena Katzke^1,12  Vittorio Krogh^1,13  Maria-Jose Sánchez^1,14  Marina Kvaskoff^1,15  Nasser Laouali^1,15  Yahya Mahamat-Saleh^1,15  Elisabete Weiderpass^1,16  Augustin Scalbert^1,16  Emily Sonestedt^1,17  Anne Tjønneland^1,18  Anja Olsen^1,18  Antonio Agudo^1,19  Valerie Cayssials^1,19  Izar de Villasante^1,19  Marta Crous-Bou^1,19  Catalina Londoño^1,19  Raul Zamora-Ros^1,19 

[1] Cancer Registry and Histopathology Unit, “Civic M.P. Arezzo” Hospital ASP, 97100 Ragusa, Italy;Cancer Risk Factors and Life-Style Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network-ISPRO, 50139 Florence, Italy;Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), 28029 Madrid, Spain;Department of Clinical Sciences, Obstetrics and Gynecology, Umeå University, 90187 Umeå, Sweden;Department of Clinical and Biological Sciences, University of Turin, 10124 Turin, Italy;Department of Clinical and Experimental Medicine, Federico II University, 80138 Naples, Italy;Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, The Arctic University of Norway, 9019 Tromsø, Norway;Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, 14558 Nuthetal, Germany;Department of Odontology, Umeå University, 90187 Umeå, Sweden;Department of Public Health, Section for Epidemiology, Aarhus University, 8000 Aarhus, Denmark;Diagnostic Radiology Unit, Lund University, 20502 Malmö, Sweden;Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany;Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, 20133 Milan, Italy;Escuela Andaluza de Salud Pública (EASP), 18011 Granada, Spain;Institut Gustave Roussy, 94805 Villejuif, France;International Agency for Research on Cancer (IARC), 69372 Lyon, France;Nutritional Epidemiology, Department of Clinical Sciences Malmö, Lund University, 21428 Malmö, Sweden;Unit of Diet, Genes and Environment, Danish Cancer Society Research Center, 2100 Copenhagen, Denmark;Unit of Nutrition and Cancer, Cancer Epidemiology Research Programme, Catalan Institute of Oncology, Bellvitge Biomedical Research Institute (IDIBELL), 08908 Barcelona, Spain;

关键词: ovarian cancer;    polyphenols;    flavonoids;    intake;    cohort;    EPIC;   

DOI  :  10.3390/antiox10081249

来源: DOAJ

【 摘 要 】

Despite some epidemiological evidence on the protective effects of polyphenol intake on epithelial ovarian cancer (EOC) risk from case-control studies, the evidence is scarce from prospective studies and non-existent for several polyphenol classes. Therefore, we aimed to investigate the associations between the intake of total, classes and subclasses of polyphenols and EOC risk in a large prospective study. The study was conducted in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort, which included 309,129 adult women recruited mostly from the general population. Polyphenol intake was assessed through validated country-specific dietary questionnaires and the Phenol-Explorer database. During a mean follow-up of 14 years, 1469 first incident EOC cases (including 806 serous, 129 endometrioid, 102 mucinous, and 67 clear cell tumours) were identified. In multivariable-adjusted Cox regression models, the hazard ratio in the highest quartile of total polyphenol intake compared with the lowest quartile (HR_Q4vsQ1) was 1.14 (95% CI 0.94–1.39; p-trend = 0.11). Similarly, the intake of most classes and subclasses of polyphenols were not related to either overall EOC risk or any EOC subtype. A borderline statistically significant positive association was observed between phenolic acid intake (HR_Q4vsQ1 = 1.20, 95% CI 1.01–1.43; p-trend = 0.02) and EOC risk, especially for the serous subtype and in women with obesity, although these associations did not exceed the Bonferroni correction threshold. The current results do not support any association between polyphenol intake and EOC in our large European prospective study. Results regarding phenolic acid intake need further investigation

【 授权许可】

Unknown