Microscopic polyangiitis: Modern concepts and treatment options

Научно-практическая ревматология

Zh. A. Murkamilova¹  I. O. Kudaibergenova²  I. T. Murkamilov²  V. V. Fomin³  F. A. Yusupov⁴  K. A. Aitbaev⁵  T. V. Beketova⁶ 

[1] B.N. Yeltsin Kyrgyz-Russian Slavic University;I.K. Akhunbaev Kyrgyz State Medical Academy;I.M. Sechenov First Moscow State Medical University of the Ministry of Health Care of Russian Federation (Sechenov University);Osh State University;Scientific and Research Institute of Molecular Biology and Medicine;V.A. Nasonova Research Institute of Rheumatology;

关键词: systemic vasculitis;    anca;    microscopic polyangiitis;    glomerulonephritis;    alveolitis;    myeloperoxidase;    proteinase 3;    glucocorticosteroids;    rituximab;    cytostatics;   

DOI  :  10.47360/1995-4484-2021-608-614

来源: DOAJ

【 摘 要 】

The article summarizes the modern concepts of microscopic polyangiitis (MPA), a primary ANCA-associated systemic necrotizing vasculitis without immune globulin deposition (pauci-immune) that affects mainly small vessels, while granulomatous inflammation is absent. Necrotizing glomerulonephritis is very common and pulmonary capillaritis often occurs. MPA can cause rapidly progressive damage to organ systems. The modern possibilities of MPA treatment, primarily anti-B cell therapy with rituximab, are discussed.

【 授权许可】

Unknown