MAP3K Family Review and Correlations with Patient Survival Outcomes in Various Cancer Types

Frontiers in Bioscience-Landmark

Andrew Rivera¹  Thomas Cheng¹  Matthew E. Burow¹  Gabrielle O. Windsor¹  Bridgette M. Collins-Burow¹  Minh N. Tran¹  Khoa Nguyen¹  Abraham B. Chabot¹  Sean B. Lee²  Jane E. Cavanaugh³  Patrick T. Flaherty³  David H. Drewry⁴ 

[1] Department of Medicine, Tulane University School of Medicine, New Orleans, LA 70112, USA;Department of Pathology and Laboratory Medicine, Tulane University School of Medicine, New Orleans, LA 70112, USA;Department of Pharmacological Sciences, Division of Medicinal Chemistry, Mylan School of Pharmacy, Duquesne University, Pittsburgh, PA 15218, USA;UNC Eshelman School of Pharmacy and UNC Lineberger Comprehensive Cancer Center, Chemical Biology and Medicinal Chemistry Division, SGC-UNC, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA;

关键词: map kinases;    mapk;    map3k;    understudied kinase;    dark kinome;    illuminating the druggable genome;    cancer;   

DOI  :  10.31083/j.fbl2705167

来源: DOAJ

【 摘 要 】

The mitogen-activated protein kinase (MAPK) pathways are ubiquitous in cellular signaling and are essential for proper biological functions. Disruptions in this signaling axis can lead to diseases such as the development of cancer. In this review, we discuss members of the MAP3K family and correlate their mRNA expression levels to patient survival outcomes in different cancers. Furthermore, we highlight the importance of studying the MAP3K family due to their important roles in the larger, overall MAPK pathway, relationships with cancer progression, and the understudied status of these kinases.

【 授权许可】

Unknown