Interactions Between Epilepsy and Plasticity

Pharmaceuticals

José J. Jarero-Basulto¹  Yadira Gasca-Martínez¹  Martha C. Rivera-Cervantes¹  Alfredo I. Feria-Velasco¹  Carlos Beas-Zarate²  Mónica E. Ureña-Guerrero³ 

[1] Cellular Neurobiology Laboratory, Cell and Molecular Biology Department, CUCBA, University of Guadalajara, 45220 Zapopan, Jalisco, Mexico;Development and Neural Regeneration Laboratory, Cell and Molecular Biology Department, CUCBA, University of Guadalajara, 45220 Zapopan, Jalisco, Mexico;Neurotransmission Biology Laboratory, Cell and Molecular Biology Department, CUCBA, University of Guadalajara, 45220 Zapopan, Jalisco, Mexico;

关键词: seizures;    hippocampus;    granular cells;    plasticity;    epilepsy;   

DOI  :  10.3390/ph11010017

来源: DOAJ

【 摘 要 】

Undoubtedly, one of the most interesting topics in the field of neuroscience is the ability of the central nervous system to respond to different stimuli (normal or pathological) by modifying its structure and function, either transiently or permanently, by generating neural cells and new connections in a process known as neuroplasticity. According to the large amount of evidence reported in the literature, many stimuli, such as environmental pressures, changes in the internal dynamic steady state of the organism and even injuries or illnesses (e.g., epilepsy) may induce neuroplasticity. Epilepsy and neuroplasticity seem to be closely related, as the two processes could positively affect one another. Thus, in this review, we analysed some neuroplastic changes triggered in the hippocampus in response to seizure-induced neuronal damage and how these changes could lead to the establishment of temporal lobe epilepsy, the most common type of focal human epilepsy.

【 授权许可】

Unknown