Appropriate Antibiotic Use and Associated Factors in Vietnamese Outpatients

Healthcare

Tam T. Le¹  Lam V. Nguyen²  Thao H. Nguyen³  Lien T. T. Pham⁴  Phuong M. Nguyen⁵  Thang Nguyen⁶  Suol T. Pham⁶  Mai T. Vi⁶  Anh L. Bui⁶  Nguyet K. Nguyen⁶  Hung D. Tran⁷  Katja Taxis⁸ 

[1] Can Tho University of Medicine and Pharmacy Hospital, Can Tho City 900000, Vietnam;Department of Anatomy, Can Tho University of Medicine and Pharmacy, Can Tho City 900000, Vietnam;Department of Clinical Pharmacy, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City 700000, Vietnam;Department of Medicinal Chemistry, Can Tho University of Medicine and Pharmacy, Can Tho 900000, Vietnam;Department of Pediatrics, Can Tho University of Medicine and Pharmacy, Can Tho City 900000, Vietnam;Department of Pharmacology and Clinical Pharmacy, Can Tho University of Medicine and Pharmacy, Can Tho City 900000, Vietnam;Faculty of Nursing, Can Tho University of Medicine and Pharmacy, Can Tho City 900000, Vietnam;Groningen Research Institute of Pharmacy, University of Groningen, 9713 AV Groningen, The Netherlands;

关键词: appropriate antibiotic usage;    associated factors;    antibiotics;    outpatients;    Vietnam;   

DOI  :  10.3390/healthcare9060693

来源: DOAJ

【 摘 要 】

Background: Inappropriate antibiotic use among outpatients is recognized as the primary driver of antibiotic resistance. A proper understanding of appropriate antibiotic usage and associated factors helps to determine and limit inappropriateness. We aimed to identify the rate of appropriate use of antibiotics and identify factors associated with the inappropriate prescriptions. Methods: We conducted a cross-sectional descriptive study in outpatient antibiotic use at a hospital in Can Tho City, Vietnam, from August 1, 2019, to January 31, 2020. Data were extracted from all outpatient prescriptions at the Medical Examination Department and analyzed by SPSS 18 and Chi-squared tests, with 95% confidence intervals. The rationale for antibiotic use was evaluated through antibiotic selection, dose, dosing frequency, dosing time, interactions between antibiotics and other drugs, and general appropriate usage. Results: A total of 420 prescriptions were 51.7% for females, 61.7% with health insurance, and 44.0% for patients with one comorbid condition. The general appropriate antibiotic usage rate was 86.7%. Prescriptions showed that 11.0% and 9.5% had a higher dosing frequency and dose than recommended, respectively; 10.2% had an inappropriate dosing time; 3.1% had drug interactions; and only 1.7% had been prescribed inappropriate antibiotics. The risk of inappropriate antibiotic use increased in patients with comorbidities and antibiotic treatment lasting >7 days (p < 0.05). Conclusions: The study indicated a need for more consideration when prescribing antibiotics to patients with comorbidities or using more than 7 days of treatment.

【 授权许可】

Unknown