Stem Cell Transplantation Therapy and Neurological Disorders: Current Status and Future Perspectives

Biology

Mayeen Uddin Khandaker¹  Amany Abdel-Rahman Mohamed²  Fahad A. Alhumaydhi³  Talha Bin Emran⁴  Mahfuzul Islam⁵  Muniruddin Ahmed⁵  Mohammad Harun-Or-Rashid⁵  Mohammad Mominur Rahman⁵  Mohammad Rezaul Islam⁵  Sumit Das⁵  Mohammad Touhidul Islam⁵  Mohammad Borhan Uddin⁵  Mohammad Saidur Rahaman⁵  Gomaa Mostafa-Hedeab⁶  Mohammad Rashed Iqbal Faruque⁷  Sabirin Abdullah⁷ 

[1] Centre for Applied Physics and Radiation Technologies, School of Engineering and Technology, Sunway University, Bandar Sunway 47500, Selangor, Malaysia;Department of Forensic Medicine and Toxicology, Zagazig University, Zagazig 4511, Egypt;Department of Medical Laboratories, College of Applied Medical Sciences, Qassim University, Buraydah 52571, Saudi Arabia;Department of Pharmacy, BGC Trust University Bangladesh, Chittagong 4381, Bangladesh;Department of Pharmacy, Faculty of Allied Health Sciences, Daffodil International University, Dhaka 1207, Bangladesh;Pharmacology Department & Health Sciences Research Unit, Medical College, Jouf University, Sakaka 72446, Saudi Arabia;Space Science Center, Universiti Kebangsaan Malaysia, Bangi 43600, Selangor, Malaysia;

关键词: neurodegenerative diseases;    neurons;    Parkinson’s disease;    red blood cell;    stem cell;    stroke;   

DOI  :  10.3390/biology11010147

来源: DOAJ

【 摘 要 】

Neurodegenerative diseases are a global health issue with inadequate therapeutic options and an inability to restore the damaged nervous system. With advances in technology, health scientists continue to identify new approaches to the treatment of neurodegenerative diseases. Lost or injured neurons and glial cells can lead to the development of several neurological diseases, including Parkinson’s disease, stroke, and multiple sclerosis. In recent years, neurons and glial cells have successfully been generated from stem cells in the laboratory utilizing cell culture technologies, fueling efforts to develop stem cell-based transplantation therapies for human patients. When a stem cell divides, each new cell has the potential to either remain a stem cell or differentiate into a germ cell with specialized characteristics, such as muscle cells, red blood cells, or brain cells. Although several obstacles remain before stem cells can be used for clinical applications, including some potential disadvantages that must be overcome, this cellular development represents a potential pathway through which patients may eventually achieve the ability to live more normal lives. In this review, we summarize the stem cell-based therapies that have been explored for various neurological disorders, discuss the potential advantages and drawbacks of these therapies, and examine future directions for this field.

【 授权许可】

Unknown